Start date is by mutual arrangement, with the possibility to start immediately
How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world's leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our community!
A PhD student position funded by the Swiss National Science Foundation (SNSF) is available in the newly founded group of project leader Dr. Fengjie Wu, who is a recent Ambizione awardee hosted by Prof. Sebastian Hiller.
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The project studies the fundamental mechanism of G protein-coupled receptors (GPCRs) signaling by applying and developing unique cutting-edge NMR technology. Further biophysical methods (cryo-EM, ITC) are integrated in the workflow. A key part of this project will be the development of novel paramagnetic NMR methods and effective isotope labeling methods.
The research will dive into the atomic level to investigate the conformational dynamics of GPCRs. Such in-depth information will explain the functions of natural ligands or synthetic drugs in GPCR signaling and pharmacology. Based on the functional understanding, opportunities for new drug design will emerge.
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